Magnesium L-threonate is a chelated form of magnesium. It can cross the blood-brain barrier easier than other magnesium supplements. This is a patented chemical compound that is sold commercially.
Pre-clinical studies show that it can improve memory performance
Magnesium is important for a number of processes in the body. One of its functions is to regulate a range of neuronal signaling pathways, including the expression of the NMDA glutamate receptor subunit NR2B. Several animal studies have shown that increased magnesium levels may enhance memory. However, this effect has not yet been observed in humans. In fact, only about 70 percent of Americans meet the recommended amount of magnesium. There is growing evidence that magnesium supplementation may benefit humans with Alzheimer’s disease, but more clinical studies are needed to determine its actual effects.
A study conducted by Wu et al. in flies showed that the addition of magnesium to the diet enhanced memory performance. The authors suggested that the effect was attributed to an increase in synapse density in the hippocampal region. This was accompanied by an increase in the expression of the NR2B NMDA receptor subunit, which is essential for normal memory.
Another study performed in Ohio examined the effects of Magtein, a form of magnesium l-threonate. Researchers found that the supplementation had an effect on extinction and spatial working memory, among other mental processes. While a few rats showed no change, others showed a decrease in memory performance.
Another study investigated the effect of Magtein on anxiety and recall. It was found that the Magtein-treated rats were less stressed while performing cognitive tasks. They also showed significant reductions in anxiety and improved mental clarity.
Although not all animals in the study showed an improvement, the study did reveal that the effects of supplemental magnesium were statistically significant. Taking the dietary supplement every day accelerated the learning process in older rats.
As expected, Magtein had a positive effect on the aforementioned spatial working memory test. Additionally, the Magtein-treated rats exhibited an increase in the extinction rate, which was a positive indicator that the substance reached the brain. Interestingly, the rats in the group that received a combination of magnesium chloride and gluconate did not have a significant increase in the amount of magnesium in their spinal fluid.
Several other pre-clinical studies have shown that magnesium supplements increase memory in fruit flies. These findings suggest that Mg2+-enhanced memory requires regulated neuronal Mg2+ efflux. Specifically, the UEX gene, which encodes a conserved CNNM-type Mg2+-eflux transporter, has a putative cyclic nucleotide-binding domain. Flies lacking this gene exhibited memory deficits.
Currently, there is no approved treatment for the memory deficits associated with Alzheimer’s. However, these results suggest that magnesium is an important part of synaptic plasticity, which has been shown to improve memory performance in many rodent models. Given the positive effects that it has on the brain, more clinical studies are needed to investigate the actual effects of supplemental magnesium.
Magtein, an ingredient branded by Magceutics, has been used to show that it can affect extinction and other aspects of cognitive function. Unlike magnesium chloride, it can cross the blood-CSF barrier and can be readily absorbed.
It may increase serotonin levels
Magnesium is important for many chemical processes in the body, including its ability to reduce levels of oxidative stress. Studies suggest that low magnesium levels are linked to stress and depression. The resulting symptoms can be physical, including shivering, muscle twitching and abnormal heartbeat. In addition, magnesium appears to reduce severity of movement disorders in animal models. However, the mechanism by which it works is not fully understood.
A study conducted in mice found that mice with high levels of magnesium in the cerebrospinal fluid displayed an antidepressant response to ketamine. When the animals were genetically modified to inhibit the release of brain-derived neurotrophic factor (BDNF), the mice did not respond to the drug. This suggests that the BDNF pathway may not be a major mechanism involved in the response to ketamine.
One of the primary excitatory neurotransmitters in the brain, glutamate, has been hypothesized to play a role in numerous mental health conditions. Excess glutamate in the brain can lead to excitotoxicity, which in turn can cause cell death. Magnesium, on the other hand, keeps glutamate within healthy levels and can help prevent this type of damage.
Several studies have shown that magnesium improves symptoms of depression and anxiety. Studies also show that it can be used in combination with standard antidepressant treatment. Currently, there are no randomized clinical trials on the effects of magnesium alone. But the use of magnesium in combination with other forms of therapy, such as cognitive behavioral therapy, may have therapeutic benefits.
Magnesium has also been reported to improve learning and memory. It has also been observed to reduce restless leg syndrome, a condition that often accompanies anxiety and depression. Other studies have shown that it can increase the level of serotonin in the blood. Serotonin is thought to play a critical role in mood and sexual desire.
Magnesium also acts as an inhibitor of the N-methyl-D-aspartate receptor (NMDA), a protein that is involved in neurotransmitter release. In this situation, magnesium can block NMDA receptor activity, increasing nitric oxide production and preventing the development of reactive oxygen species. These reactive oxygen species can lead to atrophy of cells and decreased BDNF production.
In addition, magnesium may also be involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, an area of the brain that has been linked to depression. Low magnesium levels in the central nervous system are associated with an increased level of adrenocorticotropic hormones, a factor that promotes neuronal hyperexcitability and increases the likelihood of developing anxiety and depression.
Magnesium also appears to improve symptoms of ADHD. Two studies found that lower magnesium levels are common in children with ADHD. Interestingly, only two studies looked at the effect of magnesium on the diets of people with schizophrenia.
Although there are several studies that link magnesium to depression and anxiety, there are not enough studies to determine whether it is the main culprit. Moreover, there are other factors that can influence discrepancies between findings. Those include the geographical location, the comorbidities of the patients, smoking and unhealthy dietary patterns.
It may help with migraines
Magnesium is an important mineral for a number of purposes in the body. It’s needed for nerve impulses, muscle contractions and heart beats. In addition, magnesium is an electrolyte and carries electrical charges. This makes it a great candidate for preventing migraines.
There are several forms of magnesium, including magnesium lactate, magnesium threonate and magnesium carbonate. All of these have been studied in relation to headache prevention. However, the best form of magnesium for migraines is magnesium threonate.
The American Headache Society (AHS) recommends magnesium supplementation. Studies have found that magnesium may help to prevent migraines and improve the quality of life for those who suffer from them. Other benefits of magnesium include reducing post-concussion syndrome and improving muscle cramps.
While there is not a lot of information about what the ideal dosage for magnesium is for migraine prevention, a 400 mg daily dose is considered a safe and reasonable level. Another way to get your recommended dosage is to take a magnesium oxide tablet. These are inexpensive and do not require a prescription. They have been reported to have a good safety profile. Some doctors recommend taking magnesium oxide tablets during pregnancy.
Magnesium can be absorbed by the body through food. However, if you have digestive problems, you might not be able to absorb enough of this mineral. If you suffer from frequent migraines, your doctor will likely determine the appropriate amount of magnesium for you. For pregnant women, a dosage of 350-400 mg of magnesium oxide a day is suggested.
There are other magnesium supplements available, such as magnesium glycinate, magnesium sulfate and magnesium ascorbate. These forms of magnesium are all bioavailable in the body. Aside from being a good migraine prophylaxis, magnesium may also be effective at reducing the symptoms of asthma, phonophobia and cluster headaches.
Although there is still more research to be done, magnesium is a good choice for a number of reasons. It’s inexpensive and has fewer side effects than other migraine medications. Many people who take magnesium are able to stop or reduce their migraines.
As with all medications, it is essential to speak with your doctor to ensure that you are getting the right dose and that you’re not experiencing any adverse side effects. You should also make sure that you have the proper insurance coverage. Finally, you should talk to your doctor if you are planning on becoming pregnant. During pregnancy, you should only use magnesium if your doctor says that it’s safe.
Migraines can be very unpleasant and disruptive. When you have a headache, you may experience nausea, sensitivity to light and sound, and pain in your head. You may also experience visual disturbances such as flashing lights, blurred vision and drowsiness. And if you are in the hospital, you may experience changes in your blood pressure, pulse rate and heart rate.