S-Adenosyl-L-Methionine (SAMe) is an amino acid that has been shown to have a number of health benefits. It is also important to note that there are some side effects that you should be aware of. These may include a tingling or numbing sensation in your mouth, increased urination, or diarrhea. You should also be aware that it may interact with other drugs.
It may improve cognitive performance
S-adenosyl-L-methionine, or SAMe for short, is a metabolite of the human liver. Its functions range from serving as a cofactor for protein phosphatase 2A to storing large molecule ATP. Taking vitamin B12 and folate might reduce your SAMe quotient. A well balanced diet containing plenty of fatty fish, legumes, vegetables, fruits, nuts and seeds will ensure that you’re in the best health possible. The latest buzz is that it has been found to be a promising antioxidant. For the health minded, it’s a no brainer. Despite its proven benefits, it is still a mystery to some. Hopefully, researchers will eventually wrap their brains around its mystery. Until then, the SAMe skeptics skulk in the shadows. Fortunately, SAMe can be taken as a pill or a supplement. One caveat is that there are no standardized doses to be had. To ensure a dose that is right for you, do a bit of detective work. You might be pleasantly surprised.
S-adenosyl-L-methionine may not be the most efficacious of metabolites, but it is still an important contributor to your health. In particular, the liver is your scribe.
It protects ob/ob mice from CYP2E1-mediated liver injury
Obese mice with low levels of S-adenosyl-L-methionine (SAM) are protected from CYP2E1-mediated liver damage. In addition, obese mice with low SAM levels show lower levels of triglycerides and serum transaminases, lipid peroxidation and caspase-3 activity.
This study investigated the effect of dietary and environmental factors on CYP2E1-mediated liver injury in wild type and ob/ob mice. In addition, we assessed the hepatotoxicity of CYP2E1-LPS/TNF using a pyrazole model. The pyrazole model has been used to assess the role of oxidative/nitrosative stress, NF-kB, MAPK, and mitochondrial dysfunction in the pathogenesis of hepatotoxicity.
In a pyrazole model, adenoviruses expressing human CYP2E1 produced elevated CYP2E1 and hepatotoxicity. Moreover, inducing CYP2E1 expression by ethanol treatment potentiated the induction of CYP2E1 and LPS-induced liver injury. However, hepatocytes with high CYP2E1 expression were more toxic than control hepatocytes. It has been observed that induction of CYP2E1 in the liver increases the production of ROS and TBARs, which is a downstream mediator of CYP2E1-LPS/TNF hepatotoxicity. These results suggest that dietary and environmental factors modulate the levels of CYP2E1.
To examine the hepatotoxicity of CYP2E1-LPS/TNF, mice were fed either a rodent chow diet or a liquid diet with 10% carbohydrate. Wild type and ob/ob mice were given either a dextrose-based liquid diet or an ethanol-based liquid diet. Both treatments were given daily and ad libitum for 12 h.
In addition, hepatocytes isolated from the liver of mice fed a liquid diet were analyzed. FGF21 was measured by Quantikine ELISA kit. Western blots were performed on chromatin, which was purified from viable liver cells.
We found that hepatocytes with higher CYP2E1 expression were more susceptible to TNFa induced toxicity. Furthermore, hepatocytes treated with cyclosporin A were not susceptible to pyrazole plus LPS-induced hepatocyte necrosis. This suggests that CYP2E1-LPS/TNF may sensitize hepatocytes to TNFa mediated toxicity by promoting mitochondrial permeability transition and increased oxidant stress. CYP2E1-LPS/TNF treatment was also more cytotoxic to mice with ob/ob mice. Interestingly, hepatocytes with high TG content were more sensitive to CYP2E1-LPS/TNF in AlbCre-Fgf21 mice.
CYP2E1-LPS/TNF potentiates hepatotoxicity through the inactivation of NF-kB protective pathways. This suggests that alcohol may inhibit NF-kB activation in hepatocytes and suppress the production of hepatocyte protective factors.
It may interact with other drugs
S-Adenosyl-L-Methionine (SAMe) is a naturally occurring chemical component. This molecule is involved in many important processes in the body, including cellular growth, hormone production, and the breakdown of brain chemicals. In addition, it helps maintain the action of several hormones. It can also aid in the synthesis of neurotransmitters.
Although there are no specific studies to support its use for treating depression, a metabolite of methionine has been reported to be effective for a number of patients suffering from depression. Studies have found that SAMe may help reduce symptoms of depression by enhancing the synthesis of neurotransmitters.
There are a number of ways that SAMe can be taken orally. The drug is derived from the amino acid l-methionine, which is an essential amino acid for human growth. SAMe participates in more than 40 biochemical reactions. Among the most significant functions it performs is to help the body synthesize methionine. Another benefit of taking SAMe is that it maintains the phospho-bilipid layer in cell membranes.
However, there are a few risks associated with using SAMe. One of the main risks is that the supplement may cause liver damage. Because of this, it is important to discuss this drug with a physician before taking it. Also, SAMe may interact with certain medicines, vitamins, and herbal products.
Taking SAMe can be dangerous for people who are already prone to liver disease. Additionally, SAMe may worsen liver disease in people with hepatitis. Lastly, people who are breastfeeding should not take it.
Some research suggests that SAMe can be an effective treatment for nerve problems in patients with AIDS. Researchers have also noted that it may have benefits for people who are experiencing symptoms of osteoarthritis. But more studies are needed to find out if it is an effective treatment for liver disease.
Before taking SAMe, it is important to check with your doctor to make sure it is safe for you. Tell your doctor if you are pregnant or breastfeeding, if you are using any medications, or if you have ever had a serious illness.
Side effects
S-Adenosyl-L-Methionine is a dietary supplement that is used to treat a number of disorders. Some of the disorders that S-Adenosyl-L-Methionine may help with include liver problems and joint pain. However, it can also cause side effects, so be sure to talk to your doctor about them.
S-Adenosyl-L-Methionine should not be given to people who are pregnant or breastfeeding. People with liver problems or AIDS should not use S-Adenosyl-L-Methionine. This is because the compound can promote infection in these people.
If you are taking medication, watch your symptoms for signs of overdose. If you think you have overdosed, contact your doctor or emergency room immediately. You should also bring your medicine container, if possible.
Before you start taking S-Adenosyl-L-Methionine, tell your health care provider about all of your current medications. Be sure to tell them if you are taking a prescription drug, illegal drugs, or dietary supplements. Similarly, make sure to tell them if you have any allergies or if you have recently stopped taking any medications.
For most people, the side effects of S-Adenosyl-L-Methionine are relatively minor. In some cases, though, it can cause serious side effects. These can include nausea, diarrhoea, headache, hypotension, and joint pain. Also, it can cause drowsiness.
If you are planning on taking S-Adenosyl-L-Methionine, check with your doctor or pharmacist to see what the best dosage is for you. Taking more than the prescribed amount of the compound can lead to poisoning. A common side effect of S-Adenosyl-L-Methionine medicine is hypotension.
